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boron neutron capture therapy 2

malignant glioma 2

molecular classification 2

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Frontiers of Medicine doi: 10.1007/s11684-023-1017-7

Abstract: The association of neurogenesis and gliogenesis with glioma remains unclear.Furthermore, the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinctSome specific genes not expressed in normal immune cells were found in glioma-infiltrating lymphocytesFor example, glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptorsIGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,

Keywords： single-cell RNA-seq     glioma     radial glia     primitive oligodendrocyte precursor cell     immune escape    

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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: However, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7cHere, we confirmed that RGS16 is upregulated in glioma tissues and that high expression of RGS16 is associatedEctopic deletion of RGS16 significantly suppressed glioma cell proliferation and migration both inThus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and mayserve as a potential prognostic biomarker and therapeutic target in glioma.

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 551-561 doi: 10.1007/s11684-020-0760-2

Abstract: Glioma is the most common lethal tumor of the human brain.The median survival of patients with primary World Health Organization grade IV glioma is only 14.6 monthsThe underlying mechanism of glioma recurrence and evolution patterns of glioma are different from thoseHowever, the detailed reasons for the progression and recurrence of glioma remain controversial.In this review, we introduce the different mechanisms involved in glioma progression, including tumor

Keywords： glioma     evolution mechanism     strategies     tumor heterogeneity     secondary glioma    

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Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy

TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 49-53 doi: 10.1007/s11684-007-0010-x

Abstract: The aim of this paper is to construct a specific and high-performance gene therapy system for glioma.and then constructed GFAP-Baxα gene expressing system and determined its promoting of apoptosis in gliomaThe glioma cells showed typical apoptotic signs 90 hours after the transient transfection of GFAP-BaxαIn these primary experiments, it showed that 6HRE-GFAPBaxα system could promote glioma cell apoptosisIt was specific and effective for glioma gene therapy.

Keywords： GFAP-Baxα     BT325     Fibrillary     apoptotic     specificity    

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Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 150-156 doi: 10.1007/s11684-013-0267-1

Abstract:

Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decades, and these markers have made great contributions to the accuracy of diagnosis, therapeutic decision making, and prognosis of patients. However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classification system based purely on histopathology. Great efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide treatment. In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas.

Keywords： malignant glioma     molecular biomarker     IDH1     MGMT     molecular classification    

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Experimental study on BPA uptake of glioma cell lines

Yang Lei,Wang Xiao,Sui Li,Kong Fuquan,Hao Xiaojuan,Zheng Jieying,Ma Nanru,Cui Suzhen,Liu Quanwei,Zhao Kui

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 85-90

Abstract:

Objective: to evaluate the incorporation of BPA by glioma cell lines,cells was increasing with the increasing concentration of BPA, and the boron concentration ratios of gliomaConclusion: BPA has a selectivity for glioma cells, and the results of the efflux assay confirm the temperature

Keywords： boron neutron capture therapy     BPA     glioma cell line     ICP AES    

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Boron neutron capture therapy for glioblastoma of prospects and confused

Zhou Youxin,Sun Ting,Yang Weilian,Du Ziwei

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 82-84

Abstract:

Boron neutron capture therapy (BNCT) is a selective radiotherapy of damage tumor cells, and α particle produced by which is effective to prevent glioblastoma multiform recurrence. Clinical trails of BNCT were carried out in fifties to sixties of 20 century in developed countries, but it was limited because of the development of boron carrier and neutron source. This is a review of BNCT prospect on glioblastoma multiform.

Keywords： boron neutron capture therapy     glioblastoma multiform     glioma stem cells    

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Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device Article

R. Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander

Engineering 2015, Volume 1, Issue 3,   Pages 344-350 doi: 10.15302/J-ENG-2015077

Abstract:

Convection-enhanced delivery (CED) is a promising technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6% (w/w) agarose tissue phantoms with isothermal conditions at 15 °C, 20 °C, 25 °C, and 30 °C. Infusion metrics were quantified using a custom shadowgraphy setup and image-processing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof-of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 °C showing a 7-fold increase at 100 min over the 15 °C isothermal case. Infusions during photothermal heating (1064 nm at 500 mW) showed a similar effect with a 3.5-fold increase at 4 h over the control (0 mW). These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal.

Keywords： near-infrared laser     thermochemotherapy     agarose     photothermal heating     micro-catheter     malignant glioma    

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Title Author Date Type Operation

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Journal Article

Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy

TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo

Journal Article

Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Journal Article

Experimental study on BPA uptake of glioma cell lines

Yang Lei,Wang Xiao,Sui Li,Kong Fuquan,Hao Xiaojuan,Zheng Jieying,Ma Nanru,Cui Suzhen,Liu Quanwei,Zhao Kui

Journal Article

Boron neutron capture therapy for glioblastoma of prospects and confused

Zhou Youxin,Sun Ting,Yang Weilian,Du Ziwei

Journal Article

Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device

R. Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander

Journal Article